IL33 Receptor Deficiency Leads To Steroid Resistant Asthma Due To TSLP-driven Increase In IL9+ILC2s And Mast Cells
نویسندگان
چکیده
منابع مشابه
TSLP-tickled mast cells
If you suffer a skin allergy, don’t be so quick to blame your T cells; they might not be behind it. Allakhverdi and colleagues now show on page 253 that mast cells, activated by a cytokine from epithelial cells, can jumpstart T cell–independent inflammation. Skin and epithelial cells irritated by allergens or by injury produce a cytokine called thymic stromal lymphopoietin (TSLP). This cytokine...
متن کاملResponse to C3a, mast cells, and asthma.
This is in response to a “Letter to the Editor (1)” by Dr. Bradding regarding our manuscript entitled “Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact” that was published in your journal recently (2). Dr. Bradding contends that our manuscript, which utilizes a C3a-responsive human mast cell line, is misleading because “it ignores wealth of cons...
متن کاملFrataxin inactivation leads to steroid deficiency in flies and human ovarian cells.
Friedreich ataxia (FA), the most common inherited autosomal-recessive ataxia in Caucasians, is characterized by progressive degeneration of the central and peripheral nervous system, hypertrophic cardiomyopathy and increased incidence of diabetes. FA is caused by a GAA repeat expansion in the first intron of the gene encoding frataxin, an evolutionarily conserved mitochondrial protein, which re...
متن کاملSteroid-resistant asthma.
The current study examined whether alterations in glucocorticoid receptor (GR) binding contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with forced expiratory volume in 1 s (FEV1) < 70% predicted were studied. Patients were classified as steroid sensitive (SS) if their morning FEVI increased > 30% after a I-wk course of oral prednisone 20 mg twice daily and st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2018
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.12.006